Protein Details: Inward rectifier potassium channel 2
Protein ID
ICDB_Pro_0681
Protein Name
Inward rectifier potassium channel 2
Gene Name
KCNJ2; IRK1
Organism
Homo sapiens (Human)
Length
427 amino acids
AlphaFoldDB
AF-P63252-F1-model_v4.pdb
Function
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
Sequence
Ligand Binding
Binding Site
255
Disease
Andersen Cardiodysrhythmic Periodic Paralysis and Short Qt Syndrome 3
Location
Heart; brain; placenta; lung; skeletal muscle; and kidney. Diffusely distributed throughout the brain.
DOI ID
10.1097/00001756-199412000-00024; 10.1016/0378-1119(95)00244-z; 10.1111/j.1469-7793.1998.303bw.x; 10.1016/s0014-5793(01)02202-5; 10.1152/ajpheart.1995.268.1.h506; 10.1073/pnas.102609499; 10.1161/circresaha.109.197558; 10.1016/j.ab.2014.07.006; 10.1126/sciadv.abq8489; 10.1016/s0092-8674(01)00342-7; 10.1086/342360; 10.1172/jci15183; 10.1016/j.bbrc.2005.05.054; 10.1161/01.res.0000162101.76263.8c; 10.1136/jmg.2006.040816; 10.1093/hmg/ddm034
RefSeq
NP_000882.1